Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NMT2 | O60551 | 1/20 | 0.48 |
| ▸ | NMT1 | P30419 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370339 | 0.87 | NPC1 (0.64) | GAAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL30718462 | 0.87 | NPC1 (0.64) | GAAALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL6981447 | 0.80 | NPC1 (0.68) | GAASMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL7903033 | 0.79 | RAB9A (0.57) | GAASMN1; SMN2ALDH1A1KDM4EHPGD | |
| SCHEMBL5798864 | 0.76 | ALDH1A1 (0.45) | GAAALDH1A1MEN1KMT2ANMT2 | |
| SCHEMBL13748708 | 0.75 | MCHR1 (0.53) | — | |
| SCHEMBL5803358 | 0.75 | HPGD (0.49) | GAAHPGDMEN1NPC1RAB9A | |
| SCHEMBL880654 | 0.74 | NPC1 (0.51) | SMN1; SMN2ALDH1A1KDM4EMEN1NPC1 | |
| SCHEMBL29642942 | 0.74 | PLAU (0.52) | ALDH1A1KDM4ENPC1CA12CA1 | |
| SCHEMBL31488089 | 0.74 | NPC1 (0.51) | SMN1; SMN2ALDH1A1KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264496-A1 | Substituted indoline and indole derivatives | H. LUNDBECK A/S (DK) | 2006-11-23 | — | — | US | disclosed |
| CN-1777582-A | Substituted indoline and indole derivatives | LUNDBECK & CO AS H (DK) | 2006-05-24 | — | — | CN | disclosed |
| EP-1631546-A1 | SUSTITUTED INDOLINE AND INDOLE DERIVATIVES | H. Lundbeck A/S (DK) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004096767-A1 | SUSTITUTED INDOLINE AND INDOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2004-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264496-A1 | Substituted indoline and indole derivatives | IDO1, IDO2, INMT | GAA 2838/4885SMN1; SMN2 3318/4885ALDH1A1 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.