Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.66 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266215 | 0.84 | P2RY14 (0.53) | MAPTSIRT6ADRB1LMNAALDH1A1 | |
| SCHEMBL1673550 | 0.84 | SIGMAR1 (0.52) | MAPTADRB1ALDH1A1SLC18A3POLB | |
| Hydrochloric Acid SCHEMBL2143909 | 0.83 | P2RY14 (0.52) | MAPTSIRT6ADRB1LMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL25322434 | 0.83 | SIGMAR1 (0.50) | MAPTADRB1ALDH1A1SLC18A3POLB | |
| SCHEMBL223626 | 0.81 | MAPT (1.00) | MAPTSIRT6ADRB1LMNACTSL | |
| SCHEMBL85552 | 0.81 | MAPT (1.00) | MAPTSIRT6ADRB1LMNACTSL | |
| SCHEMBL6607374 | 0.81 | MAPT (1.00) | MAPTSIRT6ADRB1LMNACTSL | |
| SCHEMBL378458 | 0.80 | MAPT (0.96) | MAPTSIRT6ADRB1LMNACTSL | |
| SCHEMBL4433804 | 0.79 | SIRT6 (0.71) | MAPTSIRT6ADRB1LMNAALDH1A1 | |
| SCHEMBL942183 | 0.79 | SIRT6 (0.87) | MAPTSIRT6ADRB1LMNACTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654238-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005009978-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | disclosed |