Sugi Predict

Sugi Predict / Compounds / SCHEMBL5801741

SCHEMBL5801741

SCHEMBL5801741

O=c1c2ccccc2[nH]c2cc(N3CCOCC3)cc(OP(=O)(OCc3ccccc3)OCc3ccccc3)c12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KIF11 P52732 3/20 0.44
▸ PIK3CG P48736 2/20 0.43
▸ MEN1 O00255 3/20 0.42
▸ KMT2A Q03164 3/20 0.42
▸ KDM4E B2RXH2 2/20 0.42
▸ ALDH1A1 P00352 2/20 0.42
▸ MAPT P10636 2/20 0.42
▸ HPGD P15428 1/20 0.42
▸ HSD17B10 Q99714 1/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ L3MBTL1 Q9Y468 1/20 0.42
▸ PRKDC P78527 3/20 0.42
▸ CTSV O60911 2/20 0.39
▸ CTSL P07711 2/20 0.39
▸ KIT P10721 1/20 0.38
▸ FLT3 P36888 1/20 0.38
▸ ATM Q13315 3/20 0.38
▸ ABCG2 Q9UNQ0 1/20 0.38
▸ IMPDH2 P12268 1/20 0.37
▸ AURKA O14965 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14447679 0.83 ALDH1A1 (0.45) KIF11MEN1KMT2AKDM4EALDH1A1
SCHEMBL5801743 0.80 PRKDC (0.42) KIF11PIK3CGMEN1KMT2AKDM4E
SCHEMBL5451016 0.78 PRKDC (0.41) PIK3CGMEN1KMT2APRKDCKIT
SCHEMBL14802149 0.77 KDM4E (0.47) KIF11MEN1KMT2AKDM4EALDH1A1
SCHEMBL5448683 0.76 PRKDC (0.49) KIF11PIK3CGPRKDCATM
SCHEMBL5440644 0.73 PRKDC (0.55) KIF11PIK3CGMEN1KMT2AKDM4E
SCHEMBL5454450 0.71 PRKDC (0.48) ALDH1A1MAPTHPGDL3MBTL1PRKDC
SCHEMBL11921370 0.69 PRKDC (0.51) PIK3CGMEN1KMT2AKDM4EALDH1A1
SCHEMBL14802146 0.66 PRKDC (0.47) ALDH1A1MAPTHPGDL3MBTL1PRKDC
SCHEMBL340989 0.64 PIK3CG (0.56) KIF11PIK3CGMEN1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8404681-B2 Xanthones, thioxanthones and acridinones as DNA-PK inhibitors LUITPOLD PHARMACEUTICALS, INC. (US) 2013-03-26 — — US disclosed
US-8404681-B2 Xanthones, thioxanthones and acridinones as DNA-PK inhibitors LUITPOLD PHARMACEUTICALS, INC. (US) 2013-03-26 — — US disclosed
US-8404681-B2 Xanthones, thioxanthones and acridinones as DNA-PK inhibitors LUITPOLD PHARMACEUTICALS, INC. (US) 2013-03-26 — — US disclosed
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors LUITPOLD PHARMACEUTICALS, INC. 2007-07-19 — — US disclosed
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors LUITPOLD PHARMACEUTICALS, INC. 2007-07-19 — — US disclosed
EP-1660473-A2 XANTHONES, THIOXANTHONES AND ACRIDINONES AS DNA-PK INHIBITORS Luitpold Pharmaceuticals, Inc. (US) 2006-05-31 — — EP disclosed
WO-2004085418-A2 XANTHONES, THIOXANTHONES AND ACRIDINONES AS DNA-PK INHIBITORS LUITPOLD PHARMACEUTICALS, INC. (US) 2004-10-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070167441-A1 Xanthones, thioxanthones and acridinones as dna-pk inhibitors DCK, DTYMK, XPA KIF11 2778/4885PIK3CG 958/4885MEN1 3846/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.