Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 8/20 | 0.50 |
| ▸ | MAOB | P27338 | 8/20 | 0.50 |
| ▸ | KDM1A | O60341 | 8/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 3/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811976 | 0.74 | KDM1A (0.61) | MAOAMAOBKDM1ARCOR1 | |
| SCHEMBL15922990 | 0.71 | HSD11B1 (0.54) | MAOAMAOBKDM1ARCOR1 | |
| SCHEMBL15922992 | 0.71 | HSD11B1 (0.54) | MAOAMAOBKDM1ARCOR1 | |
| SCHEMBL8766756 | 0.71 | MAOA (0.48) | MAOAMAOBKDM1ARCOR1 | |
| SCHEMBL9125527 | 0.67 | MAOA (0.40) | MAOAMAOBKDM1A | |
| SCHEMBL1318340 | 0.67 | MAOA (1.00) | MAOAMAOBKDM1ARCOR1LOXL2 | |
| SCHEMBL9439377 | 0.67 | MAOA (0.48) | MAOAMAOBKDM1ACALM1 | |
| SCHEMBL27672235 | 0.65 | MAOA (0.47) | MAOAMAOBKDM1ARCOR1LOXL2 | |
| Hydrochloric Acid SCHEMBL1318464 | 0.65 | MAOA (0.95) | MAOAMAOBKDM1ARCOR1LOXL2 | |
| SCHEMBL23950409 | 0.64 | MAOA (0.61) | MAOAMAOBKDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006059304-A2 | NOVEL LACTAME DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-08 | — | — | WO | disclosed |
| WO-2006058546-A1 | NOVEL LACTAME DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-06-08 | — | — | WO | disclosed |