SCHEMBL5803755

SCHEMBL5803755

[CH]c1ccccc1OC(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD1 P21728 1/20 0.42
SLC22A12 Q96S37 1/20 0.41
KMT2A Q03164 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
HTT P42858 1/20 0.39
ALDH1A1 P00352 2/20 0.36
POLB P06746 1/20 0.35
ALOX12 P18054 1/20 0.35
KDM4E B2RXH2 2/20 0.34
NR1I2 O75469 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PTGES2 Q9H7Z7 1/20 0.34
GAA P10253 2/20 0.33
CYP2D6 P10635 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
KCNH2 Q12809 1/20 0.33
ADRA1A P35348 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4654255 0.82 DRD1 (0.48) DRD1SLC22A12KMT2ASMN1; SMN2HTT
SCHEMBL338466 0.76 IRAK4 (0.47) KMT2AALDH1A1POLBKDM4EGAA
SCHEMBL338467 0.76 IRAK4 (0.47) KMT2AALDH1A1POLBKDM4EGAA
SCHEMBL7782409 0.73 KMT2A (0.53) DRD1KMT2ASMN1; SMN2HTTALDH1A1
SCHEMBL13361872 0.73 DRD1 (0.43) DRD1SLC22A12KMT2ASMN1; SMN2HTT
SCHEMBL11382835 0.73 CA1 (0.39) KMT2AHTTALDH1A1L3MBTL1MAPT
SCHEMBL23813151 0.71 ALDH1A1 (0.48) DRD1KMT2ASMN1; SMN2HTTALDH1A1
SCHEMBL8047355 0.71 ALDH1A1 (0.50) DRD1KMT2ASMN1; SMN2HTTALDH1A1
SCHEMBL112838 0.71 ALDH1A1 (0.50) DRD1KMT2ASMN1; SMN2HTTALDH1A1
SCHEMBL7674410 0.71 DRD1 (0.42) DRD1SLC22A12KMT2ASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006093518-A2 THIENYL COMPOUNDS FOR TREATING VIRUS-RELATED CONDITIONS APATH, LLC (US) 2006-09-08 WO disclosed