Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTR1E | P28566 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19337474 | 0.82 | ADRA2A (0.42) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL4654255 | 0.82 | DRD1 (0.48) | ALDH1A1MAPTKMT2AHTTL3MBTL1 | |
| SCHEMBL900624 | 0.79 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL18189403 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL25044027 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL23326007 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL30017347 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL900625 | 0.79 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL28531282 | 0.78 | LMNA (0.43) | ALDH1A1LMNAMAPTKMT2AMEN1 | |
| SCHEMBL220092 | 0.76 | ADRA2A (0.49) | ALDH1A1LMNAMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-6263678-A | — | — | None | — | — | JP | disclosed |
| US-11760701-B2 | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YROK (US) | 2023-09-19 | — | — | US | disclosed |
| US-11760701-B2 | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YROK (US) | 2023-09-19 | — | — | US | disclosed |
| US-20210032181-A1 | DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-02-04 | — | — | US | disclosed |
| US-20200121677-A1 | SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (US) | 2020-04-23 | — | — | US | disclosed |
| US-20190055257-A1 | SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-21 | — | — | US | disclosed |
| CN-108430471-A | Factor xia inhibitors | 默沙东公司 | 2018-08-21 | — | — | CN | disclosed |
| US-10005786-B2 | Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of MGLUR2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-26 | — | — | US | disclosed |
| US-10005785-B2 | Substituted 6,7-dihydropyrazolo[1,5-a] pyrazines as negative allosteric modulators of mGlUR2 receptors | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-26 | — | — | US | disclosed |
| CN-104910161-B | Pyrazolopyrimidine compound and method as JAK inhibitor | 健泰科生物技术公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-102884047-B | 2-pyridone compounds | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2015-11-25 | — | — | CN | disclosed |
| CN-102482284-B | Pyrazolopyrimidine compounds and methods as JAK inhibitors | GENENTECH, INC. (US) | 2015-11-25 | — | — | CN | disclosed |
| CN-104910161-A | Pyrazolopyrimidine JAK inhibitor compounds and methods | GENENTECH INC | 2015-09-16 | — | — | CN | disclosed |
| CN-104119238-A | Preparation method for 4-(chlorodifluoromethoxy)aniline | KINGCHEM LIAONING CHEMICAL CO LTD | 2014-10-29 | — | — | CN | disclosed |
| US-20120232265-A1 | 1,2-Disubstituted Heterocyclic Compounds | ENVIVO PHARMACEUTICALS, INC. | 2012-09-13 | — | — | US | disclosed |
| CN-102482284-A | Pyrazolopyrimidine compounds and methods as JAK inhibitors | GENENTECH INC | 2012-05-30 | — | — | CN | disclosed |
| WO-2000075093-A1 | METHOD OF MAKING α,α,α-TRIFLUOROMETHOXYBENZENES | OCCIDENTAL CHEMICAL CORPORATION (US) | 2000-12-14 | — | — | WO | disclosed |
| US-5484932-A | Halogenation processes in advantageous solvents, and novel bistrifluoromethyl-polyfluoroalkoxybenzenes | BAYER AKTIENGESELLSCHAFT (DE) | 1996-01-16 | — | — | US | disclosed |
| US-5440051-A | Halogenating by metering into reaction vessel at the same time as chlorine in presence of solvent or absence of solvent to form a chemical intermediates for fungicides or insecticides | BAYER AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |
| JP-H06263678-A | CHLORODIFLUOROMETHOXYPHENYL DERIVATIVE | F HOFFMANN LA ROCHE AG | 1994-09-20 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232265-A1 | 1,2-Disubstituted Heterocyclic Compounds | PDE12, PDE7A, PDE10A | ALDH1A1 699/4885LMNA 3565/4885MAPT 476/4885 |
| US-20190055257-A1 | SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM5, GRM1 | ALDH1A1 4145/4885LMNA 4573/4885MAPT 1193/4885 |
| US-10005786-B2 | Substituted 6,7-dihydropyrazolo[1,5-a]pyrazines as negative allosteric modulators of MGLUR2 receptors | GRM2, GRM5, GRM1 | ALDH1A1 3723/4885LMNA 4481/4885MAPT 1265/4885 |
| US-20210032181-A1 | DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME | AFF2, AFF4, AFF1 | ALDH1A1 1490/4885LMNA 2457/4885MAPT 2445/4885 |
| US-20200121677-A1 | SUBSTITUTED 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINES AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS | GRM2, GRM5, GRM1 | ALDH1A1 4145/4885LMNA 4573/4885MAPT 1193/4885 |
| US-11760701-B2 | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same | AFF2, AFF4, AFF1 | ALDH1A1 1490/4885LMNA 2457/4885MAPT 2445/4885 |
| US-10005785-B2 | Substituted 6,7-dihydropyrazolo[1,5-a] pyrazines as negative allosteric modulators of mGlUR2 receptors | GRM2, GRM5, GRM1 | ALDH1A1 3723/4885LMNA 4481/4885MAPT 1265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.