Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806550 | 0.82 | SMN1; SMN2 (0.40) | MAPTNPC1RAB9AALDH1A1HTT | |
| SCHEMBL5801973 | 0.80 | HTR7 (0.44) | PDGFRBHTR7S1PR1KITDHODH | |
| SCHEMBL17280155 | 0.79 | MEN1 (0.49) | PDGFRBMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL17279819 | 0.78 | NPC1 (0.50) | PDGFRBMAPTNPC1RAB9AKDM4E | |
| SCHEMBL5803521 | 0.78 | DHODH (0.43) | MAPTLMNAKMT2AHTR7S1PR1 | |
| SCHEMBL7142078 | 0.77 | NPC1 (0.51) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL650259 | 0.77 | NPC1 (0.51) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL11771726 | 0.76 | KDM4E (0.50) | PDGFRBMAPTNPC1RAB9AKDM4E | |
| SCHEMBL8142183 | 0.76 | AURKA (0.47) | PDGFRBMAPTNPC1RAB9AKDM4E | |
| SCHEMBL5802708 | 0.75 | ALOX5 (0.42) | PDGFRBMAPTRAB9AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723117-A2 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005086836-A2 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |