Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | ICMT | O60725 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5803521 | 0.81 | DHODH (0.43) | HTR7S1PR1KITDHODHICMT | |
| SCHEMBL5802708 | 0.80 | ALOX5 (0.42) | HTR7PDGFRBPDGFRA | |
| SCHEMBL5804196 | 0.80 | PDGFRB (0.44) | HTR7S1PR1KITDHODHPDGFRB | |
| SCHEMBL5806550 | 0.76 | SMN1; SMN2 (0.40) | S1PR1MAPK14 | |
| SCHEMBL7159559 | 0.75 | ALDH1A1 (0.47) | KITPDGFRBPDGFRA | |
| SCHEMBL7159598 | 0.75 | KMO (0.45) | PDGFRBPDGFRA | |
| SCHEMBL7161302 | 0.75 | KMO (0.43) | PDGFRBPDGFRA | |
| SCHEMBL10355347 | 0.71 | DCUN1D1 (0.49) | — | |
| SCHEMBL6859787 | 0.71 | AMY1A (0.49) | — | |
| SCHEMBL11350778 | 0.71 | HPGD (0.40) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723119-A1 | ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005087747-A1 | ION CHANNEL MODULATORS | WYETH (US) | 2005-09-22 | — | — | WO | disclosed |