Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.47 |
| ▸ | PTGES | O14684 | 8/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | FPR1 | P21462 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805188 | 0.90 | ALDH1A1 (0.46) | PTGESALOX5 | |
| SCHEMBL5807526 | 0.89 | EGFR (0.58) | EGFRERBB2PTGESALOX5LMNA | |
| SCHEMBL5807982 | 0.88 | PTGES (0.56) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5807053 | 0.83 | PTGES (0.52) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5804879 | 0.82 | PTGES (0.51) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5820740 | 0.81 | ALDH1A1 (0.43) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5807553 | 0.81 | EGFR (0.50) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5806852 | 0.81 | ALDH1A1 (0.50) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5808774 | 0.80 | ALDH1A1 (0.59) | EGFRERBB2PTGESALOX5MAPK13 | |
| SCHEMBL5805227 | 0.79 | EGFR (0.47) | EGFRERBB2PTGESALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |