Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 13/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | STK17B | O94768 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | NPR3 | P17342 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306751 | 0.91 | STK17B (0.37) | AAK1STK17BSTK17ANPR3CA12 | |
| SCHEMBL5305779 | 0.86 | AAK1 (0.36) | AAK1STK17BSTK17ANPR3CA12 | |
| SCHEMBL5794142 | 0.86 | MEN1 (0.40) | MEN1KMT2AAAK1THRBSTK17B | |
| SCHEMBL5306992 | 0.85 | ATR (0.36) | AAK1STK17BSTK17ANPR3CA12 | |
| SCHEMBL5791173 | 0.83 | GPR119 (0.39) | AAK1 | |
| SCHEMBL8140939 | 0.81 | AAK1 (0.47) | AAK1STK17BSTK17A | |
| SCHEMBL5792631 | 0.76 | STK17B (0.42) | AAK1STK17BSTK17A | |
| SCHEMBL5306935 | 0.76 | AAK1 (0.36) | AAK1STK17BSTK17ANPR3 | |
| SCHEMBL5306326 | 0.74 | STK17B (0.47) | AAK1STK17BSTK17A | |
| SCHEMBL5370705 | 0.73 | MAPT (0.41) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |