Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | PTGES | O14684 | 3/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806852 | 0.90 | ALDH1A1 (0.50) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL5808774 | 0.89 | ALDH1A1 (0.59) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL5807982 | 0.87 | PTGES (0.56) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL5806836 | 0.85 | POLB (0.51) | ALDH1A1PTGESALOX5POLBHPGD | |
| SCHEMBL5805188 | 0.84 | ALDH1A1 (0.46) | ALDH1A1PTGESALOX5POLBNTRK1 | |
| SCHEMBL5820953 | 0.84 | HTR6 (0.51) | HTR6MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL5806408 | 0.83 | MAPT (0.47) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL5808587 | 0.83 | LMNA (0.45) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL5807053 | 0.83 | PTGES (0.52) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 | |
| SCHEMBL5804879 | 0.82 | PTGES (0.51) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |