Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 12/20 | 0.47 |
| ▸ | MMP2 | P08253 | 12/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP14 | P50281 | 2/20 | 0.34 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805194 | 1.00 | LMNA (0.52) | LMNAGAAMMP9MMP2CA12 | |
| SCHEMBL5808038 | 0.88 | LMNA (0.40) | LMNAGAAMMP9MMP2CA12 | |
| SCHEMBL5808036 | 0.88 | LMNA (0.40) | LMNAGAAMMP9MMP2CA12 | |
| SCHEMBL10649843 | 0.77 | GAA (0.65) | LMNAGAACA2ALDH1A1POLB | |
| SCHEMBL5804845 | 0.76 | CA2 (0.57) | MMP9MMP2CA12CA2CA9 | |
| SCHEMBL2650730 | 0.71 | LMNA (0.47) | LMNAGAAALDH1A1 | |
| SCHEMBL2653000 | 0.71 | LMNA (0.47) | LMNAGAAALDH1A1 | |
| SCHEMBL15761364 | 0.70 | GAA (1.00) | LMNAGAACA12CA2CA9 | |
| SCHEMBL29751607 | 0.70 | GAA (1.00) | LMNAGAACA12CA2CA9 | |
| SCHEMBL3691573 | 0.67 | MMP9 (0.61) | MMP9MMP2MMP3MMP1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |