Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.57 |
| ▸ | CA12 | O43570 | 8/20 | 0.57 |
| ▸ | CA9 | Q16790 | 8/20 | 0.57 |
| ▸ | CA1 | P00915 | 7/20 | 0.57 |
| ▸ | MMP9 | P14780 | 10/20 | 0.54 |
| ▸ | MMP2 | P08253 | 9/20 | 0.54 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | MMP25 | Q9NPA2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804960 | 0.83 | CA2 (0.53) | CA2CA12CA9CA1MMP9 | |
| SCHEMBL14540198 | 0.83 | MMP2 (0.52) | CA2CA12CA9CA1MMP9 | |
| SCHEMBL5805194 | 0.76 | LMNA (0.52) | CA2CA12CA9CA1MMP9 | |
| SCHEMBL5805191 | 0.76 | LMNA (0.52) | CA2CA12CA9CA1MMP9 | |
| SCHEMBL13272367 | 0.74 | MMP9 (0.63) | MMP9MMP2MMP1MMP3MMP8 | |
| SCHEMBL14540195 | 0.73 | GRM5 (0.44) | CA2CA12CA9CA1MMP9 | |
| SCHEMBL1348016 | 0.70 | CA2 (0.43) | CA2CA12CA9CA1CA7 | |
| SCHEMBL313011 | 0.70 | CA2 (0.46) | CA2CA12CA9CA1CA5A | |
| SCHEMBL13247263 | 0.69 | MMP9 (0.40) | CA2CA12CA9CA1MMP9 | |
| SCHEMBL13743183 | 0.69 | CA2 (0.56) | CA2CA12CA9CA1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |