Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804123 | 0.88 | ADRA1A (0.46) | TDP1SMN1; SMN2CHRM2HTR1AADRA2A | |
| SCHEMBL9622333 | 0.86 | TDP1 (0.59) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL5805447 | 0.84 | SIGMAR1 (0.47) | CHRM2HTR1AADRA2ACHRM1DRD1 | |
| SCHEMBL28669826 | 0.77 | TDP1 (0.48) | TDP1TP53ALDH1A1HPGDALOX15 | |
| SCHEMBL4261642 | 0.77 | TAAR1 (0.48) | TDP1TP53ALDH1A1HPGDALOX15 | |
| SCHEMBL680098 | 0.77 | TDP1 (0.54) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL10431545 | 0.77 | TDP1 (0.54) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL15302665 | 0.77 | TP53 (0.46) | TDP1TP53ALDH1A1LOXL2 | |
| SCHEMBL9622329 | 0.77 | TDP1 (0.59) | TDP1ALDH1A1HPGDALOX15ALOX12 | |
| SCHEMBL9622811 | 0.77 | TDP1 (0.59) | TDP1ALDH1A1HPGDALOX15ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006069096-A1 | SILANOL DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |