SCHEMBL580603

SCHEMBL580603

c1ccc(C(SOSC(c2ccccc2)(c2ccccc2)c2ccccc2)(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 11/20 0.43
MAPK1 P28482 1/20 0.40
KCNN4 O15554 4/20 0.39
TSHR P16473 2/20 0.39
ALDH1A1 P00352 2/20 0.39
ALOX15 P16050 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19514668 0.87 KIF11 (0.53) KIF11MAPK1TSHRALDH1A1
SCHEMBL19514691 0.83 KIF11 (0.58) KIF11
SCHEMBL977258 0.83 KIF11 (0.58) KIF11
SCHEMBL1126001 0.76 CA1 (0.41) KIF11MAPK1TSHRALDH1A1
SCHEMBL5507220 0.74 KIF11 (0.44) KIF11MAPK1KCNN4TSHRALDH1A1
SCHEMBL114237 0.74 KIF11 (0.50) KIF11MAPK1KCNN4TSHRALDH1A1
SCHEMBL22892484 0.74 KIF11 (0.44) KIF11MAPK1KCNN4ALDH1A1ALOX15
SCHEMBL7715769 0.73 KIF11 (0.48) KIF11MAPK1KCNN4TSHRALDH1A1
SCHEMBL34009 0.73 KIF11 (0.48) KIF11MAPK1KCNN4TSHRALDH1A1
SCHEMBL23499891 0.71 NFE2L2 (0.40) KIF11TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210189392-A1 S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS ALIGOS THERAPEUTICS, INC. 2021-06-24 US claimed
CN-104725628-B A kind of single functionalization branched polyethylene glycol, preparation method and its bio-related substance containing degradable group 厦门赛诺邦格生物科技股份有限公司 2018-04-17 CN claimed
CN-104530417-B A kind of multiple functionalized H types polyethyleneglycol derivative and preparation method thereof 厦门赛诺邦格生物科技股份有限公司 2017-09-08 CN claimed
CN-104530415-B A kind of different functionalization Y types polyethyleneglycol derivative, preparation method and its bio-related substance 厦门赛诺邦格生物科技股份有限公司 2017-09-01 CN claimed
CN-104109235-B A kind of single functionalized poly (ethylene glycol), preparation method and its bio-related substance with nitrogen-atoms branch centers 厦门赛诺邦格生物科技股份有限公司 2017-07-18 CN claimed
CN-104725628-A Single functional branched polyethylene glycol containing degradable radical, preparation method and biorelevant substance of single functional branched polyethylene glycol XIAMEN SINOPEG BIOTECH CO LTD 2015-06-24 CN claimed
CN-104530415-A Hetero-functionalized Y-type polyethylene glycol derivative, preparation method and biologically related substance thereof XIAMEN SINOPEG BIOTECH INC 2015-04-22 CN claimed
CN-104530417-A Multifunctional H-type polyethylene glycol derivative and preparation method thereof XIAMEN SINOPEG BIOTECH INC 2015-04-22 CN claimed
CN-104109235-A Mono-functionalized polyethylene glycol with nitrogen atom branched center and its preparation method and biologically-relevant matter XIAMEN SINOPEG BIOTECH CO LTD 2014-10-22 CN claimed
US-20020190759-A1 Electrochemically accelerated self-assembly of molecular devices NATIONAL SCIENCE FOUNDATION 2002-12-19 US claimed
US-12611462-B2 Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof CITY OF HOPE (US) 2026-04-28 US disclosed
US-12252511-B2 Process for the preparation of cyclic depsipeptides ONKURE, INC. (US) 2025-03-18 US disclosed
US-20240116989-A1 PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES ONKURE, INC. (US) 2024-04-11 US disclosed
US-11739123-B2 Process for the preparation of cyclic depsipeptides ONKURE, INC. (US) 2023-08-29 US disclosed
US-11629171-B2 Beta-hairpin peptidomimetics SPEXIS AG (CH) 2023-04-18 US disclosed
WO-1995001990-A1 HEMOREGULATORY PENTA- OR HEXAPEPTIDES NYCOMED PHARMA A.S (NO) 1995-01-19 WO disclosed
CN-1091138-A Vaccine DEAKIN RES LTD (AU) 1994-08-24 CN disclosed
WO-1994005311-A1 RETRO-, INVERSO-, AND RETRO-INVERSO SYNTHETIC PEPTIDE ANALOGUES DEAKIN RESEARCH LIMITED (AU) 1994-03-17 WO disclosed
WO-1991012021-A2 THERAPEUTIC AGENTS, AND INTERMEDIATES FOR THE SYNTHESIS THEREOF OXFORD VIROLOGY PLC (GB) 1991-08-22 WO disclosed
US-4346187-A AND ORGANIC BROMINE COMPOUND BORG-WARNER CHEMICALS, INC. (US) 1982-08-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11739123-B2 Process for the preparation of cyclic depsipeptides VIP, LPXN, NGLY1 KIF11 2181/4885MAPK1 1658/4885KCNN4 3425/4885
US-12611462-B2 Compounds and compositions including phosphorothioated oligodeoxynucleotide, and methods of use thereof STAT3, NSUN2, STAT1 KIF11 4625/4885MAPK1 1692/4885KCNN4 3119/4885
US-20240116989-A1 PROCESS FOR THE PREPARATION OF CYCLIC DEPSIPEPTIDES VIP, LPXN, NGLY1 KIF11 2181/4885MAPK1 1658/4885KCNN4 3425/4885
US-11629171-B2 Beta-hairpin peptidomimetics POLL, POLQ, HBZ KIF11 2142/4885MAPK1 2245/4885KCNN4 3057/4885
US-12252511-B2 Process for the preparation of cyclic depsipeptides VIP, LPXN, NGLY1 KIF11 2181/4885MAPK1 1658/4885KCNN4 3425/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.