Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806959 | 0.86 | RAB9A (0.54) | RAB9ANPC1POLBPARP1DPP8 | |
| SCHEMBL5811080 | 0.79 | TSHR (0.48) | POLBKDM4EHTTKMT2ATSHR | |
| SCHEMBL10577926 | 0.79 | KDM4E (0.67) | RAB9ANPC1PARP1DPP8DPP7 | |
| SCHEMBL5807809 | 0.79 | HSD11B1 (0.47) | NPC1POLBALDH1A1KDM4EHPGD | |
| SCHEMBL3923742 | 0.76 | MAPT (0.48) | ALDH1A1KDM4EHTTMEN1KMT2A | |
| SCHEMBL29569463 | 0.74 | NPC1 (0.78) | RAB9ANPC1DPP8DPP7ROCK2 | |
| SCHEMBL5672650 | 0.74 | DPP8 (0.61) | RAB9ANPC1POLBPARP1DPP8 | |
| SCHEMBL2334856 | 0.73 | HDAC3 (0.65) | RAB9ANPC1POLBPARP1DPP8 | |
| SCHEMBL6228768 | 0.72 | HDAC3 (0.68) | RAB9ANPC1POLBPARP1DPP8 | |
| SCHEMBL6790178 | 0.72 | GRIN2D (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |