Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811080 | 0.86 | TSHR (0.48) | HSD11B1POLBKMT2ATSHRL3MBTL1 | |
| SCHEMBL3923742 | 0.86 | MAPT (0.48) | KMT2AMAPTMEN1KDM4EALDH1A1 | |
| SCHEMBL5807811 | 0.84 | HSD11B1 (0.48) | HSD11B1POLBHPGDSMN1; SMN2NPC1 | |
| SCHEMBL30786265 | 0.79 | HPGD (0.50) | HSD11B1POLBHPGDSMN1; SMN2NPC1 | |
| SCHEMBL1118921 | 0.79 | KDM4E (0.49) | HPGDTSHRKDM4EALDH1A1CYP2C9 | |
| SCHEMBL5806958 | 0.79 | RAB9A (0.53) | POLBHPGDSMN1; SMN2NPC1KMT2A | |
| SCHEMBL18549597 | 0.76 | PDE5A (0.47) | SMN1; SMN2TSHRMAPTKDM4ECYP1A2 | |
| SCHEMBL10574538 | 0.74 | ALDH1A1 (0.58) | POLBHPGDSMN1; SMN2NPC1KMT2A | |
| SCHEMBL13833166 | 0.73 | CXCR4 (0.50) | HPGDTSHRNPSR1L3MBTL1MAPT | |
| SCHEMBL2829094 | 0.72 | PIM1 (0.44) | TSHRNPSR1KDM4ELMNAMBOAT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |