Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807809 | 0.86 | HSD11B1 (0.47) | TSHRLMNAMAPTHSD11B1KDM4E | |
| SCHEMBL5811085 | 0.84 | LMNA (0.49) | TSHRLMNAMAPTHSD11B1HSD17B1 | |
| SCHEMBL3923742 | 0.83 | MAPT (0.48) | MAPTKDM4EHTTGAAKMT2A | |
| SCHEMBL15650850 | 0.80 | PARP1 (0.47) | LMNAKDM4EGLAHTTHDAC6 | |
| SCHEMBL5806958 | 0.79 | RAB9A (0.53) | TSHRKDM4EHTTKMT2APOLB | |
| SCHEMBL13621171 | 0.75 | KDM4E (0.59) | TSHRLMNAMAPTKDM4EKMT2A | |
| SCHEMBL18549597 | 0.74 | PDE5A (0.47) | TSHRMAPTKDM4EGAAMBOAT4 | |
| SCHEMBL15651529 | 0.72 | HRH3 (0.49) | KDM4EKMT2AL3MBTL1 | |
| SCHEMBL2829475 | 0.72 | PARP1 (0.54) | TSHRKDM4EMBOAT4TDP1 | |
| SCHEMBL15652284 | 0.72 | HTR3A (0.58) | IRAK4HSD11B1KDM4EGLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |