SCHEMBL5808115

SCHEMBL5808115

[O]C(=O)c1ccc([C]=O)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
GSK3B P49841 2/20 0.34
MMP2 P08253 1/20 0.33
MMP12 P39900 1/20 0.33
RARB P10826 1/20 0.32
RARG P13631 1/20 0.32
PARP15 Q460N3 1/20 0.31
PARP10 Q53GL7 1/20 0.31
PARP2 Q9UGN5 1/20 0.31
ESR1 P03372 1/20 0.31
ESR2 Q92731 1/20 0.31
SRD5A2 P31213 1/20 0.31
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
PKM P14618 1/20 0.31
HPGD P15428 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2641715 0.87 KMT2A (0.47) CA1CA2TP53TSHRGSK3B
SCHEMBL27352439 0.83 CES1 (0.44) CA1CA2TSHRGSK3BSRD5A2
Bicarbonate SCHEMBL11402475 0.83 TSHR (0.35) CA1CA2TP53TSHRMMP2
SCHEMBL11238566 0.81 SRD5A2 (0.50) CA1CA2ESR1ESR2SRD5A2
SCHEMBL536808 0.79 TSHR (0.63) CA1CA2TP53TSHRRARB
SCHEMBL14877306 0.78 CES2 (0.41) TP53TSHRRARBMAPTPKM
SCHEMBL103281 0.77 CA1 (0.37) CA1CA2TP53TSHRGSK3B
SCHEMBL8401560 0.77 CA1 (0.37) CA1CA2TP53TSHRGSK3B
SCHEMBL2163556 0.77 CA2 (0.64) CA1CA2GSK3BPARP15PARP10
SCHEMBL4757633 0.77 PARP10 (0.52) CA1CA2TSHRPARP15PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006122414-A1 DEPOT FOR SUSTAINED AND CONTROLLED DELIVERY OF METHOTREXATE MATREGEN CORP. (CA) 2006-11-23 WO claimed
US-20220033557-A1 PHOTOPOLYMERIZATION METHOD FOR PREPARING BLOCK COPOLYMER WITH MAIN-CHAIN SEMI-FLUORINATED ALTERNATING COPOLYMER SOOCHOW UNIVERSITY (CN) 2022-02-03 US disclosed
US-10059798-B2 Active ester resin, epoxy resin composition, cured product thereof, prepreg, circuit board, and build-up film DIC CORPORATION (JP) 2018-08-28 US disclosed
US-9963544-B2 Active ester resin containing phosphorus atom, epoxy resin composition and cured product thereof, prepreg, circuit board, and build-up film DIC CORPORATION (JP) 2018-05-08 US disclosed
EP-2589625-B1 THERMOSETTING RESIN COMPOSITION, CURED PRODUCT THEREOF, ACTIVE ESTER RESIN, SEMICONDUCTOR SEALING MATERIAL, PREPREG, PRINTED CIRCUIT BOARD, AND BUILD-UP FILM DAINIPPON INK & CHEMICALS (JP) 2016-10-26 EP disclosed
US-20160130391-A1 ACTIVE ESTER RESIN CONTAINING PHOSPHORUS ATOM, EPOXY RESIN COMPOSITION AND CURED PRODUCT THEREOF, PREPREG, CIRCUIT BOARD, AND BUILD-UP FILM DIC CORPORATION (JP) 2016-05-12 US disclosed
US-20150344617-A1 ACTIVE ESTER RESIN, EPOXY RESIN COMPOSITION, CURED PRODUCT THEREOF, PREPREG, CIRCUIT BOARD, AND BUILD-UP FILM DIC CORPORATION (JP) 2015-12-03 US disclosed
US-8669333-B2 Thermosetting resin composition, cured product thereof, active ester resin, semiconductor encapsulating material, prepreg, circuit board, and build-up film DIC CORPORATION (JP) 2014-03-11 US disclosed
EP-2589625-A1 THERMOSETTING RESIN COMPOSITION, CURED PRODUCT THEREOF, ACTIVE ESTER RESIN, SEMICONDUCTOR SEALING MATERIAL, PREPREG, PRINTED CIRCUIT BOARD, AND BUILD-UP FILM DIC Corporation (JP) 2013-05-08 EP disclosed
US-20130101857-A1 THERMOSETTING RESIN COMPOSITION, CURED PRODUCT THEREOF, ACTIVE ESTER RESIN, SEMICONDUCTOR ENCAPSULATING MATERIAL, PREPREG, CIRCUIT BOARD, AND BUILD-UP FILM DIC CORPORATION (JP) 2013-04-25 US disclosed
WO-2006122414-A1 DEPOT FOR SUSTAINED AND CONTROLLED DELIVERY OF METHOTREXATE MATREGEN CORP. (CA) 2006-11-23 WO disclosed
EP-0782428-A2 Z-DIRECTION LIQUID TRANSPORT MEDIUM Kimberly-Clark Worldwide, Inc. (US) 1997-07-09 EP disclosed
WO-1996007384-A2 Z-DIRECTION LIQUID TRANSPORT MEDIUM KIMBERLY-CLARK WORLDWIDE, INC. (US) 1996-03-14 WO disclosed
US-5349095-A Process for preparing hydroxyalkylbenzocyclobutenes THE DOW CHEMICAL COMPANY (US) 1994-09-20 US disclosed
US-5264613-A Process for preparing ester of hydroxymethylbenzocyclobutenes THE DOW CHEMICAL COMPANY (US) 1993-11-23 US disclosed
US-5227536-A PROCESS FOR PREPARING HYDROXYBENZOCYCLOBUTENES THE DOW CHEMICAL COMPANY (US) 1993-07-13 US disclosed