Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5808471 | 0.90 | LMNA (0.37) | LMNAMAPK1SMN1; SMN2MEN1THRB | |
| SCHEMBL5809123 | 0.88 | NTRK1 (0.38) | LMNASMN1; SMN2THRBKMT2AGAA | |
| SCHEMBL8262663 | 0.85 | NTRK1 (0.35) | LMNATHRBKMT2AGAATSHR | |
| SCHEMBL8262196 | 0.84 | GUSB (0.44) | LMNAMAPK1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5808028 | 0.84 | NTRK1 (0.35) | LMNATHRBKMT2AGAATSHR | |
| SCHEMBL5804860 | 0.84 | ALDH1A1 (0.42) | LMNASMN1; SMN2MEN1THRBKMT2A | |
| SCHEMBL5821042 | 0.84 | MAPK13 (0.43) | LMNAMAPK1SMN1; SMN2MEN1THRB | |
| SCHEMBL5806376 | 0.84 | NTRK1 (0.37) | LMNASMN1; SMN2THRBKMT2AGAA | |
| SCHEMBL5806305 | 0.83 | LMNA (0.43) | LMNAMAPK1SMN1; SMN2MEN1THRB | |
| SCHEMBL5804805 | 0.83 | MAPT (0.40) | LMNAMAPK1SMN1; SMN2MEN1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |