Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5809123 | 0.88 | NTRK1 (0.38) | NTRK1ALDH1A1ATML3MBTL1HTT | |
| SCHEMBL8262663 | 0.87 | NTRK1 (0.35) | NTRK1ALDH1A1ATML3MBTL1HTT | |
| SCHEMBL5808760 | 0.86 | PTGES (0.37) | GUSBALDH1A1PTGER3KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5808028 | 0.86 | NTRK1 (0.35) | NTRK1ALDH1A1ATML3MBTL1HTT | |
| SCHEMBL5808980 | 0.84 | LMNA (0.43) | NTRK1ALDH1A1ATML3MBTL1HTT | |
| SCHEMBL5804860 | 0.84 | ALDH1A1 (0.42) | NTRK1ALDH1A1PTGER3ATML3MBTL1 | |
| SCHEMBL5821042 | 0.84 | MAPK13 (0.43) | NTRK1ALDH1A1L3MBTL1LMNAMAPK1 | |
| SCHEMBL5806376 | 0.84 | NTRK1 (0.37) | NTRK1ALDH1A1ATML3MBTL1HTT | |
| SCHEMBL5804805 | 0.83 | MAPT (0.40) | NTRK1ALDH1A1L3MBTL1HTTLMNA | |
| SCHEMBL5807701 | 0.82 | MEN1 (0.41) | NTRK1ALDH1A1ATML3MBTL1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006075955-A1 | PYRAZOLYL ACYLSULFONAMIDE DERIVATIVES AS ENDOTHELIN CONVERTING ENZYME INHIBITORS AND USEFUL IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ASTRAZENECA AB (SE) | 2006-07-20 | — | — | WO | disclosed |