SCHEMBL5808997

SCHEMBL5808997

Cc1[nH]c2c(OCc3ccc(Cl)c(Cl)c3)nccc2c1C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.43
CYP2C19 P33261 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP2D6 P10635 1/20 0.43
RAB9A P51151 2/20 0.40
MAPT P10636 1/20 0.40
HTR6 P50406 4/20 0.38
MAOA P21397 1/20 0.38
DYRK1A Q13627 1/20 0.38
IDO1 P14902 2/20 0.38
MEN1 O00255 1/20 0.38
SLC26A4 O43511 1/20 0.38
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
MAOB P27338 1/20 0.37
SCN9A Q15858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5808896 0.86 HTR6 (0.50) CYP2C19MAPTHTR6MAOADYRK1A
SCHEMBL5811668 0.85 CYP1A2 (0.41) CYP2C19MAPTHTR6MAOADYRK1A
SCHEMBL5809894 0.84 HTR6 (0.54) CYP2C19HTR6MAOAKDM4ECYP1A2
SCHEMBL5808715 0.82 CYP1A2 (0.40) CYP2C19MAPTHTR6MAOADYRK1A
SCHEMBL5807558 0.81 MAOA (0.55) CYP2C19RAB9AMAPTMAOAKDM4E
SCHEMBL5810105 0.81 LMNA (0.51) CYP2C19MAPTHTR6MAOAIDO1
SCHEMBL5809748 0.81 CNR1 (0.40) NPC1CYP2C19CYP2D6RAB9AMAPT
SCHEMBL5811682 0.80 MAOA (0.47) CYP2C19ALDH1A1CYP2D6MAPTMAOA
SCHEMBL5810147 0.80 CYP1A2 (0.47) NPC1CYP2C19MAPTHTR6KMT2A
Hydrochloric Acid SCHEMBL5811001 0.80 CNR1 (0.39) NPC1CYP2C19ALDH1A1CYP2D6RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006025717-A1 PYRROLO[2,3-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO claimed
WO-2006025717-A1 PYRROLO[2,3-c]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 WO disclosed