Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5805083 | 0.79 | EGFR (0.47) | GAASMN1; SMN2MEN1KMT2AKDR | |
| SCHEMBL5821110 | 0.78 | KDM4E (0.44) | MDM2SMN1; SMN2LMNAALDH1A1KDR | |
| SCHEMBL28818910 | 0.75 | KDM4E (0.39) | MDM2GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4169210 | 0.73 | HMGCR (0.47) | TP53GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL5805311 | 0.73 | HTT (0.45) | SMN1; SMN2ALDH1A1KDRPOLBCYP3A4 | |
| SCHEMBL5808355 | 0.71 | KCNK9 (0.43) | GAASMN1; SMN2NPSR1CNR1KDR | |
| SCHEMBL4163228 | 0.71 | PTGS2 (0.40) | MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL5804954 | 0.70 | GCGR (0.49) | TP53GAASMN1; SMN2KMT2ALMNA | |
| SCHEMBL5806885 | 0.70 | CHEK1 (0.42) | TP53SMN1; SMN2ALDH1A1CNR1CDK2 | |
| SCHEMBL5808019 | 0.70 | DEGS1 (0.44) | MEN1KMT2ARAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006110918-A1 | PYRROLE COMPOUNDS AND USES THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2006-10-19 | — | — | WO | disclosed |