Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5799269 | 0.83 | CHEK2 (0.36) | NPC1RAB9APIM1PIM3PIM2 | |
| SCHEMBL5795750 | 0.76 | MCHR1 (0.37) | MCHR1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL5797441 | 0.73 | MAPK8 (0.42) | MCHR1PIM1PIM3PIM2HTR2B | |
| SCHEMBL5795957 | 0.67 | MCHR1 (0.37) | MCHR1ALDH1A1KDM4EPIM1PIM3 | |
| SCHEMBL12595917 | 0.66 | LMNA (0.42) | MCHR1MEN1KMT2APIM1PIM3 | |
| SCHEMBL12595902 | 0.66 | LMNA (0.42) | MCHR1MEN1KMT2APIM1PIM3 | |
| SCHEMBL8481298 | 0.65 | GPR119 (0.58) | GPR119ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23965806 | 0.64 | RAB9A (0.52) | ALDH1A1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL12648936 | 0.64 | WDR5 (0.47) | MCHR1 | |
| SCHEMBL12648976 | 0.64 | WDR5 (0.47) | MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006038734-A1 | PYRIDAZINONE DERIVATIVES CYTOKINES INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2006-04-13 | — | — | WO | disclosed |