SCHEMBL5812558

SCHEMBL5812558

CCOCn1c(-c2ccc(Cl)cc2)c(C#N)c(Cl)c1C(F)(F)F

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 3/20 0.36
KDM4E B2RXH2 8/20 0.34
HPGD P15428 7/20 0.34
ALDH1A1 P00352 6/20 0.34
KMT2A Q03164 3/20 0.34
LMNA P02545 3/20 0.34
HTT P42858 2/20 0.34
MEN1 O00255 2/20 0.34
GLA P06280 1/20 0.34
GAA P10253 1/20 0.34
CRHBP P24387 1/20 0.34
CRHR2 Q13324 1/20 0.34
GRIA2 P42262 1/20 0.32
GRIA4 P48058 1/20 0.32
CNR1 P21554 1/20 0.32
SQOR Q9Y6N5 1/20 0.32
POLB P06746 2/20 0.31
MAPT P10636 1/20 0.31
NPSR1 Q6W5P4 3/20 0.31
PPARG P37231 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5819964 0.92 MAOA (0.34) RXFP1KDM4EHPGDALDH1A1KMT2A
SCHEMBL5819960 0.92 KIF11 (0.35) RXFP1ALDH1A1MAPT
SCHEMBL9567361 0.91 RXFP1 (0.35) RXFP1KDM4EHPGDALDH1A1KMT2A
SCHEMBL9015078 0.89 KDM4E (0.37) RXFP1KDM4EHPGDALDH1A1KMT2A
SCHEMBL9567338 0.89 RXFP1 (0.32) RXFP1KDM4EHPGDALDH1A1KMT2A
Chlorfenapyr SCHEMBL40337 0.88 RXFP1 (0.35) RXFP1KDM4EHPGDALDH1A1KMT2A
SCHEMBL5812533 0.88 ADORA1 (0.33) RXFP1KDM4EHPGDALDH1A1LMNA
SCHEMBL5815133 0.88 KDM4E (0.36) RXFP1KDM4EHPGDALDH1A1KMT2A
SCHEMBL5812554 0.87 CTSS (0.34) RXFP1HPGDKMT2ALMNAMEN1
Chlorfenapyr SCHEMBL28530561 0.87 RXFP1 (0.35) RXFP1KDM4EHPGDALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0895839-B1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack BASF AG (DE) 2006-09-20 EP claimed
EP-0895717-B1 Arylpyrroles for subterranean termite control BASF AG (DE) 2003-05-28 EP claimed
EP-0801896-B1 Use of arylpyrroles for the control of pyrothroid-resistant insect populations AMERICAN CYANAMID CO (US) 2000-08-30 EP claimed
EP-0492171-B1 4-Chloro-1-(ethoxymethyl)-2-(p-chlorophenyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile, and its use as insecticide, nematocide and acaricide AMERICAN CYANAMID CO (US) 2000-08-02 EP claimed
EP-0895839-A1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack American Cyanamid Company (US) 1999-02-10 EP claimed
EP-0895717-A1 Arylpyrroles for subterranean termite control American Cyanamid Company (US) 1999-02-10 EP claimed
US-5817324-A Use of arylpyrroles for the control of resistant insect populations AMERICAN CYANAMID COMPANY (US) 1998-10-06 US claimed
EP-0801896-A1 Use of arylpyrroles for the control of pyrothroid-resistant insect populations American Cyanamid Company (US) 1997-10-22 EP claimed
US-5591765-A ARYLPYRROLECARBONITRILE AMERICAN CYANAMID COMPANY (US) 1997-01-07 US claimed
EP-0491136-B1 Process for the manufacture of pesticidal 1-(alkoxymethyl)pyrrole compounds AMERICAN CYANAMID CO (US) 1996-09-18 EP claimed
US-5362746-A Process for the manufacture of insecticidal 2-aryl-1-(alkoxymethyl)-4-halo-5-(trifluoromethyl)pyrroles AMERICAN CYANAMID COMPANY (US) 1994-11-08 US claimed
US-5187184-A Mixtures of substituted arylpyrroles and arylpyrazoles AMERICAN CYANAMID COMPANY (US) 1993-02-16 US claimed
US-5151536-A Insecticides, molluscicides, miticides or nematocides AMERICAN CYANAMID COMPANY (US) 1992-09-29 US claimed
EP-0492171-A1 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles AMERICAN CYANAMID COMPANY (US) 1992-07-01 EP claimed
EP-0491136-A2 Process for the manufacture of pesticidal 1-(alkoxymethyl)pyrrole compounds AMERICAN CYANAMID COMPANY (US) 1992-06-24 EP claimed
CN-114436932-A Synthetic process of chlorfenapyr homolog 山东潍坊双星农药有限公司 2022-05-06 CN disclosed
EP-0895839-B1 Arylpyrroles for the protection of wood, wood products and wood structures from insect attack BASF AG (DE) 2006-09-20 EP disclosed
US-5187184-A Mixtures of substituted arylpyrroles and arylpyrazoles AMERICAN CYANAMID COMPANY (US) 1993-02-16 US disclosed
EP-0492125-A1 Insecticidal and synergistic miticidal compositions AMERICAN CYANAMID COMPANY (US) 1992-07-01 EP disclosed
EP-0492171-A1 2-Aryl-5-trifluoromethyl)-2-pyrroline compounds and process for the manufacture of insecticidal, 2-aryl-1-(alkoxymethyl)-4-halo-5-(trofluoromethyl) pyrroles AMERICAN CYANAMID COMPANY (US) 1992-07-01 EP disclosed