Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 13/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20270062 | 0.89 | FAAH (0.46) | FAAHKMT2AIDO1ALDH1A1HDAC3 | |
| SCHEMBL5917686 | 0.86 | FAAH (0.56) | FAAHIDO1 | |
| SCHEMBL5917702 | 0.85 | KMT2A (0.50) | KMT2AIDO1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL5917710 | 0.83 | FAAH (0.64) | FAAHKMT2AALDH1A1 | |
| SCHEMBL11918667 | 0.83 | SMN1; SMN2 (0.49) | FAAHKMT2AALDH1A1 | |
| SCHEMBL20270215 | 0.81 | KMT2A (0.42) | FAAHKMT2AALDH1A1HDAC3HDAC4 | |
| SCHEMBL5917719 | 0.81 | KMT2A (0.46) | FAAHKMT2AIDO1ALDH1A1HDAC3 | |
| SCHEMBL25337245 | 0.79 | IDO1 (0.49) | KMT2AIDO1ALDH1A1HDAC3HDAC4 | |
| SCHEMBL11918449 | 0.79 | KMT2A (0.43) | FAAHKMT2AIDO1ALDH1A1HDAC3 | |
| SCHEMBL20270602 | 0.78 | GPR119 (0.43) | FAAHKMT2AALDH1A1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12448392-B2 | Spiropiperidine derivatives | CEPHALON LLC (US) | 2025-10-21 | — | — | US | disclosed |
| US-20240166661-A1 | Spiropiperidine Derivatives | CEPHALON LLC | 2024-05-23 | — | — | US | disclosed |
| US-11878982-B2 | Spiropiperidine derivatives | 89BIO LTD (IL) | 2024-01-23 | — | — | US | disclosed |
| US-20210284651-A1 | Spiropiperidine Derivatives | CEPHALON LLC | 2021-09-16 | — | — | US | disclosed |
| US-11046707-B2 | Spiropiperidine derivatives | 89BIO LTD (IL) | 2021-06-29 | — | — | US | disclosed |
| US-20200031840-A1 | SPIROPIPERIDINE DERIVATIVES | CEPHALON LLC | 2020-01-30 | — | — | US | disclosed |
| EP-3554637-A1 | SPIROPIPERIDINE DERIVATIVES | 89Bio Ltd. (IL) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018112204-A1 | SPIROPIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2018-06-21 | — | — | WO | disclosed |
| WO-2018112204-A1 | SPIROPIPERIDINE DERIVATIVES | CEPHALON, INC. (US) | 2018-06-21 | — | — | WO | disclosed |
| US-8513232-B2 | Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513232-B2 | Substituted spirocyclic piperidine derivatives as histamine-3 (H3) receptor ligands | CEPHALON, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| EP-2250176-B1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON INC (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20110071131-A1 | Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| US-20110071131-A1 | Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands | CEPHALON, INC. (US) | 2011-03-24 | — | — | US | disclosed |
| WO-2009097567-A1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON, INC. (US) | 2009-08-06 | — | — | WO | disclosed |
| US-20060217375-A1 | New compounds | BIOVITRUM AB (SE) | 2006-09-28 | — | — | US | disclosed |
| WO-2006067224-A2 | SPIRO-BENZODIOXOLE AND SPIRO-BENZODIOXANE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | BIOVITRUM AB (PUBL) (SE) | 2006-06-29 | — | — | WO | disclosed |
| WO-2006067224-A2 | SPIRO-BENZODIOXOLE AND SPIRO-BENZODIOXANE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | BIOVITRUM AB (PUBL) (SE) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11878982-B2 | Spiropiperidine derivatives | FASN, FADS2, SCD5 | FAAH 335/4885KMT2A 4061/4885IDO1 3262/4885 |
| US-20110071131-A1 | Substituted Spirocyclic Piperidine Derivatives as Histamine-3 (H3) Receptor Ligands | HRH3, HRH4, HRH2 | FAAH 325/4885KMT2A 840/4885IDO1 667/4885 |
| US-20060217375-A1 | New compounds | HCRTR2, HCRTR1, NPY1R | FAAH 352/4885KMT2A 858/4885IDO1 653/4885 |
| US-20210284651-A1 | Spiropiperidine Derivatives | FASN, FADS2, SCD5 | FAAH 335/4885KMT2A 4061/4885IDO1 3262/4885 |
| US-20200031840-A1 | SPIROPIPERIDINE DERIVATIVES | FASN, FADS2, SCD5 | FAAH 335/4885KMT2A 4061/4885IDO1 3262/4885 |
| US-12448392-B2 | Spiropiperidine derivatives | FASN, FADS2, SCD5 | FAAH 335/4885KMT2A 4061/4885IDO1 3262/4885 |
| US-20240166661-A1 | Spiropiperidine Derivatives | FASN, FADS2, SCD5 | FAAH 335/4885KMT2A 4061/4885IDO1 3262/4885 |
| US-11046707-B2 | Spiropiperidine derivatives | FASN, FADS2, SCD5 | FAAH 335/4885KMT2A 4061/4885IDO1 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.