Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 11/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121979 | 0.96 | MEN1 (0.49) | MEN1KMT2APRKCITSHRCHRM4 | |
| SCHEMBL5130858 | 0.90 | PRKCI (0.47) | MEN1KMT2APRKCICHRM4 | |
| SCHEMBL7172866 | 0.90 | ALDH1A1 (0.52) | MEN1KMT2ATSHRALDH1A1HPGD | |
| SCHEMBL5809171 | 0.87 | PRKCI (0.48) | PRKCI | |
| SCHEMBL5121900 | 0.87 | PRKCI (0.60) | MEN1KMT2APRKCIALDH1A1ROCK2 | |
| SCHEMBL5129098 | 0.86 | ALDH1A1 (0.49) | MEN1KMT2ATSHRALDH1A1HPGD | |
| SCHEMBL5812974 | 0.85 | CHRM4 (0.40) | MEN1KMT2ATSHRSMN1; SMN2CHRM4 | |
| SCHEMBL5813822 | 0.85 | POLB (0.44) | MEN1KMT2ATSHRSMN1; SMN2CHRM4 | |
| SCHEMBL7522368 | 0.85 | ALDH1A1 (0.47) | MEN1KMT2APRKCIALDH1A1HPGD | |
| SCHEMBL7176322 | 0.84 | TSHR (0.45) | MEN1KMT2ATSHRSMN1; SMN2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |