Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823977 | 0.85 | MEN1 (0.53) | MEN1KMT2AATMDRD4DRD2 | |
| SCHEMBL5814935 | 0.82 | MAPK1 (0.62) | ALDH1A1MEN1KMT2AATMDRD2 | |
| SCHEMBL5818308 | 0.80 | MEN1 (0.53) | MEN1KMT2AATMMAPK1CHRM4 | |
| SCHEMBL5820590 | 0.79 | MEN1 (0.55) | ALDH1A1MEN1KMT2AATMDRD4 | |
| SCHEMBL5899201 | 0.79 | MEN1 (0.63) | MEN1KMT2AATMDRD4DRD2 | |
| SCHEMBL5899197 | 0.77 | MAPK1 (0.62) | ALDH1A1MEN1KMT2AATMDRD4 | |
| SCHEMBL5805864 | 0.76 | MEN1 (0.44) | MEN1KMT2AATMCHRM4LMNA | |
| SCHEMBL5820685 | 0.73 | ADRA1D (0.55) | ALDH1A1MEN1KMT2ADRD2LMNA | |
| SCHEMBL5820519 | 0.72 | HTR1A (0.54) | MEN1KMT2ADRD2 | |
| SCHEMBL8557218 | 0.72 | AVPR1A (0.60) | ALDH1A1MAPK1MAPTSMN1; SMN2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006088954-A1 | DIHYDROINDOLYL METHANONES AS ALPHA 1A/1D ADRENORECEPTOR MODULATORS FOR THE TREATMENT OF BENIGN PROSTATIC HYPERTROPHY AND LOWER URINARY TRACT SYMPTOMS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-08-24 | — | — | WO | disclosed |