Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820590 | 0.92 | MEN1 (0.55) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL5820519 | 0.88 | HTR1A (0.54) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL5814914 | 0.84 | HTR1A (0.75) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL5899207 | 0.84 | HTR1A (0.62) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL5899201 | 0.76 | MEN1 (0.63) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL9540927 | 0.74 | HTR1A (0.70) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| Hydrochloric Acid SCHEMBL7648536 | 0.73 | HTR1A (0.69) | ADRA1DADRA1AADRA1BHTR1AMEN1 | |
| SCHEMBL5819994 | 0.73 | HTR1A (0.72) | ADRA1DADRA1AADRA1BHTR1ADRD2 | |
| SCHEMBL5813989 | 0.73 | ALDH1A1 (0.50) | MEN1KMT2ADRD2ALDH1A1LMNA | |
| SCHEMBL5820432 | 0.72 | HTR1A (0.74) | ADRA1DADRA1AADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006088954-A1 | DIHYDROINDOLYL METHANONES AS ALPHA 1A/1D ADRENORECEPTOR MODULATORS FOR THE TREATMENT OF BENIGN PROSTATIC HYPERTROPHY AND LOWER URINARY TRACT SYMPTOMS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-08-24 | — | — | WO | disclosed |