Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812539 | 0.92 | NOS3 (0.40) | NOS1NOS2MAPTMAPK14KDM4E | |
| SCHEMBL5817168 | 0.91 | MAP4K4 (0.40) | KCNH2MAPK14ALDH1A1MAP4K4LMNA | |
| SCHEMBL5814921 | 0.89 | TRPC3 (0.42) | MAPTKCNH2MAPK14KDM4EALDH1A1 | |
| SCHEMBL5813472 | 0.86 | NOS1 (0.43) | NOS1NOS2MAPTKCNH2TP53 | |
| SCHEMBL5815240 | 0.86 | MAPK14 (0.49) | KCNH2MAPK14 | |
| SCHEMBL5817719 | 0.85 | NOS3 (0.41) | NOS1NOS2MAPTMAPK14KDM4E | |
| SCHEMBL5815514 | 0.85 | DGAT1 (0.53) | NOS1NOS2KCNH2DGAT1MAPK14 | |
| SCHEMBL5815323 | 0.84 | DGAT1 (0.52) | NOS1NOS2KCNH2DGAT1MAPK14 | |
| SCHEMBL5819605 | 0.83 | ALDH1A1 (0.42) | NOS2MAPTTP53MAPK14KDM4E | |
| SCHEMBL5818450 | 0.83 | DGAT1 (0.51) | NOS1NOS2KCNH2DGAT1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | claimed |