Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.69 |
| ▸ | EGFR | P00533 | 7/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820276 | 0.94 | PTGDR2 (0.65) | PTGDR2EGFRERBB2GAAPTGES | |
| SCHEMBL5813952 | 0.83 | EGFR (0.54) | PTGDR2EGFRERBB2GAAMAPT | |
| SCHEMBL5820072 | 0.82 | PTGDR2 (1.00) | PTGDR2GAAALDH1A1MAPT | |
| SCHEMBL5819527 | 0.80 | GAA (0.47) | PTGDR2GAAPTGESALOX5L3MBTL1 | |
| SCHEMBL5815917 | 0.74 | NTRK1 (0.65) | PTGDR2GAAL3MBTL1PTGS1PTGS2 | |
| SCHEMBL5819545 | 0.73 | PTGDR2 (0.46) | PTGDR2EGFRPTGESALOX5L3MBTL1 | |
| SCHEMBL19626751 | 0.72 | PTGDR2 (0.66) | PTGDR2GAAL3MBTL1PTGS1PTGS2 | |
| SCHEMBL19630969 | 0.70 | EGFR (0.68) | EGFRERBB2L3MBTL1ALDH1A1 | |
| SCHEMBL11034353 | 0.70 | EGFR (0.68) | EGFRERBB2L3MBTL1ALDH1A1MAPT | |
| SCHEMBL5544242 | 0.69 | PTGDR2 (0.76) | PTGDR2GAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |
| WO-2006085815-A1 | THIAZOLE DERIVATIVES, THEIR PROCESS FOR THEIR PREPARATION AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2006-08-17 | — | — | WO | disclosed |