Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19626522 | 0.87 | HTT (0.70) | PTGDR2HTTPTGS1PTGS2ALDH1A1 | |
| SCHEMBL19043213 | 0.86 | GAA (0.56) | PTGDR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL792073 | 0.83 | PTGS2 (0.52) | PTGDR2PTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL13002963 | 0.82 | ALDH1A1 (0.67) | PTGDR2PTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL791528 | 0.82 | PTGDR2 (0.61) | PTGDR2HTTPTGS1PTGS2ALDH1A1 | |
| SCHEMBL19626585 | 0.82 | PTGDR2 (0.61) | PTGDR2HTTPTGS1PTGS2ALDH1A1 | |
| SCHEMBL27995931 | 0.81 | HTT (0.77) | PTGDR2HTTALDH1A1MAPTMEN1 | |
| SCHEMBL5820072 | 0.80 | PTGDR2 (1.00) | PTGDR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL19626591 | 0.80 | PTGDR2 (0.58) | PTGDR2HTTPTGS1PTGS2ALDH1A1 | |
| SCHEMBL19625357 | 0.79 | HTT (0.49) | PTGDR2HTTPTGS2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | PTGDR2 443/4885HTT 3968/4885PTGS1 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.