Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 1.00 |
| ▸ | RAB9A | P51151 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.82 |
| ▸ | JAK2 | O60674 | 2/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.63 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.63 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.59 |
| ▸ | CLK2 | P49760 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380296 | 0.87 | NPC1 (1.00) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL1122533 | 0.80 | NPC1 (0.76) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL5713502 | 0.79 | NPC1 (0.72) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL15147870 | 0.78 | ROCK2 (1.00) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL9348553 | 0.78 | NPC1 (0.72) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL6816783 | 0.78 | RAB9A (0.63) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL1163706 | 0.77 | ROCK2 (0.74) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL6814633 | 0.77 | RAB9A (0.71) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL24933989 | 0.77 | NPC1 (0.71) | NPC1RAB9AALDH1A1MAPTHPGD | |
| SCHEMBL3378320 | 0.77 | RAB9A (0.80) | NPC1RAB9AALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006135383-A2 | INDAZOLES | MYRIAD GENETICS, INC. (US) | 2006-12-21 | — | — | WO | disclosed |