SCHEMBL5821649

SCHEMBL5821649

COc1ccc(-c2ncsc2-c2ccnc([C@@](C)(N)c3ccccc3)n2)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 2/20 0.39
ALDH1A1 P00352 2/20 0.38
KDM4E B2RXH2 1/20 0.38
LMNA P02545 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
ADORA1 P30542 2/20 0.37
GSK3B P49841 1/20 0.36
DPP4 P27487 1/20 0.36
MAPK13 O15264 1/20 0.36
RAF1 P04049 1/20 0.36
MAPK9 P45984 1/20 0.36
MAPK12 P53778 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36
CYP19A1 P11511 1/20 0.36
CDK5 Q00535 1/20 0.35
IKBKB O14920 1/20 0.35
NPC1 O15118 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5817990 0.87 PTGDR2 (0.36) ADORA2AADORA1GSK3BMAPK13MAPK9
SCHEMBL5812487 0.80 ADORA2A (0.39) ADORA2AADORA1DPP4MAPK14CYP19A1
SCHEMBL5819107 0.80 ADORA2A (0.38) ADORA2AKDM4ELMNAADORA1DPP4
SCHEMBL5819868 0.78 CDC7 (0.38) ADORA2AADORA1DPP4RAF1MAPK14
SCHEMBL5823310 0.78 ALDH1A1 (0.51) ALDH1A1KDM4ELMNANPSR1TDP1
SCHEMBL5820563 0.77 KMT2A (0.47) ALDH1A1KDM4ENPSR1IKBKBKMT2A
SCHEMBL5818970 0.76 EGFR (0.47) RAF1MAPK9
SCHEMBL5821650 0.75 MAPK13 (0.46) ALDH1A1GSK3BMAPK13MAPK9MAPK12
SCHEMBL5815370 0.74 POLB (0.40) ALDH1A1KDM4ELMNANPSR1TDP1
SCHEMBL5813457 0.72 NPC1 (0.39) ALDH1A1KDM4ECYP19A1IKBKBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006137658-A1 NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DONGBU HITEK CO., LTD. (KR) 2006-12-28 WO claimed
WO-2006137658-A1 NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME DONGBU HITEK CO., LTD. (KR) 2006-12-28 WO disclosed