Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5819549 | 0.86 | TGFBR1 (0.55) | TGFBR1MAPK14KCNH2EGFRACHE | |
| SCHEMBL5822178 | 0.82 | EGFR (0.46) | TGFBR1KCNH2EGFR | |
| SCHEMBL5818985 | 0.79 | CCNA2 (0.50) | PTGS2PTGS1TGFBR1MAPK14 | |
| SCHEMBL5818004 | 0.79 | MEN1 (0.33) | PTGS2TGFBR1MAPK14KCNH2 | |
| SCHEMBL5818469 | 0.78 | KCNH2 (0.54) | KCNH2EGFR | |
| SCHEMBL5819408 | 0.76 | KCNH2 (0.62) | KCNH2ACHE | |
| SCHEMBL5777962 | 0.74 | ALDH1A1 (0.52) | TGFBR1 | |
| SCHEMBL5815219 | 0.72 | MAPK14 (0.52) | TGFBR1MAPK14EGFR | |
| SCHEMBL5780175 | 0.71 | ADORA2A (0.36) | PTGS2PTGS1TGFBR1MAPK14 | |
| SCHEMBL5815240 | 0.71 | MAPK14 (0.49) | MAPK14KCNH2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006137658-A1 | NEW SUBSTITUTED 1,3-THIAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVING IMMUNOSUPPRESSION AND INFLAMMATION INHIBITORY ACITIVITY, INTERMEDIATE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, A PROCESS FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DONGBU HITEK CO., LTD. (KR) | 2006-12-28 | — | — | WO | disclosed |