Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5822194 | 0.77 | KMT2A (0.46) | ALDH1A1LMNAKMT2ACYP1A2CYP3A4 | |
| SCHEMBL5822163 | 0.76 | NTRK1 (0.48) | ALDH1A1LRRK2CCKARCCKBR | |
| SCHEMBL5468659 | 0.75 | NTRK1 (0.47) | KMT2ACYP1A2CYP2C19LRRK2MAPT | |
| SCHEMBL20181880 | 0.72 | ALDH1A1 (0.75) | ALDH1A1KDM4ELMNAKMT2ACYP1A2 | |
| SCHEMBL5469781 | 0.71 | PBRM1 (0.51) | ALDH1A1LMNAKMT2ALRRK2MAPT | |
| SCHEMBL5819721 | 0.71 | ALDH1A1 (0.51) | ALDH1A1KDM4ELMNAKMT2AMAPT | |
| SCHEMBL1558423 | 0.70 | ALDH1A1 (1.00) | ALDH1A1KDM4ELMNAKMT2ACYP1A2 | |
| SCHEMBL5472389 | 0.69 | CCKBR (0.39) | KDM4ELMNAKMT2ALRRK2MAPT | |
| SCHEMBL5472388 | 0.69 | CCKBR (0.39) | KDM4ELMNAKMT2ALRRK2MAPT | |
| SCHEMBL1852233 | 0.69 | CYP1A2 (0.64) | ALDH1A1KDM4ELMNAKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |