Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.48 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5468659 | 0.91 | NTRK1 (0.47) | NTRK1PRKD3ABL1DAPK3MAP4K4 | |
| SCHEMBL5469781 | 0.82 | PBRM1 (0.51) | NTRK1PRKD3ABL1DAPK3MAP4K4 | |
| SCHEMBL5472388 | 0.77 | CCKBR (0.39) | NTRK1PRKD3ABL1DAPK3MAP4K4 | |
| SCHEMBL5472389 | 0.77 | CCKBR (0.39) | NTRK1PRKD3ABL1DAPK3MAP4K4 | |
| SCHEMBL5822194 | 0.77 | KMT2A (0.46) | CCKBRCCKARALDH1A1MAPK1 | |
| SCHEMBL5813081 | 0.77 | NTRK1 (0.48) | NTRK1PRKD3ABL1DAPK3MAP4K4 | |
| SCHEMBL5822242 | 0.76 | ALDH1A1 (0.53) | LRRK2CCKBRCCKARALDH1A1 | |
| SCHEMBL5477306 | 0.68 | KDM4E (0.45) | NTRK1PRKD3ABL1DAPK3MAP4K4 | |
| SCHEMBL14320160 | 0.66 | IDO1 (0.56) | PDGFRALTKLRRK2ALDH1A1IDO1 | |
| SCHEMBL23525604 | 0.66 | IMPDH2 (0.43) | NTRK1PRKD3ABL1DAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006105796-A1 | NOVEL INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2006-10-12 | — | — | WO | disclosed |