Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Terpin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terpin SCHEMBL5377815 | 0.89 | TRPA1 (0.40) | PTGS1CES2HSD11B1TRPA1ALDH1A1 | |
| Terpin SCHEMBL9536260 | 0.89 | TRPA1 (0.40) | PTGS1CES2HSD11B1TRPA1ALDH1A1 | |
| Terpin SCHEMBL19192 | 0.89 | TRPA1 (0.40) | PTGS1CES2HSD11B1TRPA1ALDH1A1 | |
| Terpin SCHEMBL29867 | 0.87 | TRPA1 (0.39) | PTGS1HSD11B1TRPA1ALDH1A1TDP1 | |
| Terpin SCHEMBL2487459 | 0.87 | TRPA1 (0.39) | PTGS1HSD11B1TRPA1ALDH1A1TDP1 | |
| Terpin SCHEMBL5177695 | 0.85 | TRPA1 (0.38) | PTGS1HSD11B1TRPA1ALDH1A1TDP1 | |
| Terpin SCHEMBL12506199 | 0.80 | PTGS1 (0.36) | PTGS1CES2HSD11B1TRPA1ALDH1A1 | |
| Acetic Acid SCHEMBL20296825 | 0.78 | PTGS1 (0.33) | PTGS1CES2TRPA1 | |
| SCHEMBL13900364 | 0.73 | ALDH1A1 (0.39) | PTGS1HSD11B1TRPA1ALDH1A1TDP1 | |
| SCHEMBL12384745 | 0.73 | ALDH1A1 (0.39) | PTGS1HSD11B1TRPA1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2006140110-A | CARBON NANOTUBE PASTE, ELECTRON EMITTING SOURCE, FIELD EMISSION DISPLAY, AND MANUFACTURING METHOD OF THESE | MITSUBISHI CORP | 2006-06-01 | — | — | JP | disclosed |