SCHEMBL5823911

SCHEMBL5823911

Fc1ccc(C(Cl)(Cl)Cl)c(CCl)c1

nearest known ligand 0.34

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
IDO1 P14902 3/20 0.34
P2RX7 Q99572 1/20 0.32
PSEN1 P49768 1/20 0.32
PSEN2 P49810 1/20 0.32
APH1B Q8WW43 1/20 0.32
NCSTN Q92542 1/20 0.32
APH1A Q96BI3 1/20 0.32
PSENEN Q9NZ42 1/20 0.32
AGXT P21549 1/20 0.31
NR3C1 P04150 1/20 0.30
NR3C2 P08235 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A4 P31645 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5823897 0.83 IDO1 (0.42) CYP3A4TSHRMAPK1TDP1IDO1
SCHEMBL938117 0.83 IDO1 (0.46) IDO1P2RX7SLC6A2SLC6A4
SCHEMBL17414239 0.82 IDO1 (0.33) CYP3A4TSHRMAPK1TDP1IDO1
SCHEMBL9075811 0.79 RIPK1 (0.33) IDO1NR3C1NR3C2SLC6A2SLC6A4
SCHEMBL10972656 0.75
SCHEMBL28056457 0.75 IDO1 (0.40) IDO1PSEN1PSEN2APH1BNCSTN
SCHEMBL11550172 0.73 ALDH1A1 (0.42) CYP3A4TSHRMAPK1TDP1IDO1
SCHEMBL31433155 0.73 ALDH1A1 (0.42) CYP3A4TSHRMAPK1TDP1IDO1
SCHEMBL2708686 0.73 PSEN1 (0.47) IDO1PSEN1PSEN2APH1BNCSTN
SCHEMBL3978795 0.71 TSHR (0.60) CYP3A4TSHRMAPK1TDP1P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2006160635-A METHOD FOR PRODUCING 2-TRIFLUOROMETHYL-5-FLUOROBENZALDEHYDE AND ITS DERIVATIVE CENTRAL GLASS CO LTD 2006-06-22 JP disclosed
JP-2005200396-A FLUORINE-CONTAINING BENZAL CHLORIDE AND METHOD FOR PRODUCING THE SAME CENTRAL GLASS CO LTD 2005-07-28 JP disclosed
JP-2005139166-A METHOD FOR PRODUCING 4-TRIFLUOROMETHYL-3-METHYLFLUOROBENZENE CENTRAL GLASS CO LTD 2005-06-02 JP disclosed