Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807702 | 0.86 | DHODH (0.43) | MAPTTP53GAAKDM4E | |
| SCHEMBL4169210 | 0.82 | HMGCR (0.47) | HMGCRPOLBMAPTTP53MEN1 | |
| SCHEMBL5807727 | 0.81 | HMGCR (0.46) | HMGCRPOLBMAPTTP53MEN1 | |
| SCHEMBL5804849 | 0.80 | SLCO1B1 (0.45) | HMGCRPOLBMAPTMEN1KMT2A | |
| SCHEMBL11364006 | 0.78 | ALDH1A1 (0.45) | MAPTGAAKDM4ESMN1; SMN2CHEK1 | |
| SCHEMBL5808019 | 0.77 | DEGS1 (0.44) | HMGCRPOLBMAPTMEN1KMT2A | |
| SCHEMBL5805346 | 0.77 | HMGCR (0.43) | HMGCRPOLBMAPTMEN1KMT2A | |
| SCHEMBL5806553 | 0.77 | HMGCR (0.43) | HMGCRPOLBMAPTMEN1KMT2A | |
| SCHEMBL28662576 | 0.75 | MAPT (0.44) | MAPTGAAKDM4ESMN1; SMN2CHEK1 | |
| SCHEMBL5805083 | 0.74 | EGFR (0.47) | POLBMAPTMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006110918-A1 | PYRROLE COMPOUNDS AND USES THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2006-10-19 | — | — | WO | disclosed |