Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807702 | 0.92 | DHODH (0.43) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL28662576 | 0.88 | MAPT (0.44) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL5823974 | 0.78 | HMGCR (0.46) | GAAKDM4EMAPTSMN1; SMN2CHEK1 | |
| SCHEMBL10989712 | 0.76 | KDM4E (0.50) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL5821110 | 0.74 | KDM4E (0.44) | ALDH1A1HPGDKDM4EMAPTPIM1 | |
| SCHEMBL3345001 | 0.71 | KDM4E (0.49) | ALDH1A1HPGDKDM4EMAPTPIM1 | |
| SCHEMBL31567904 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL31567905 | 0.71 | ALDH1A1 (0.62) | ALDH1A1HPGDGAAKDM4EMAPT | |
| SCHEMBL29020548 | 0.70 | LMNA (0.48) | ALDH1A1HPGDGAALMNAPLA2G2A | |
| SCHEMBL30602834 | 0.70 | KDM4E (0.57) | ALDH1A1HPGDGAAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025884-A1 | 4,5-Diaryl-alpha-polyfluoroalkyl-1H-pyrrole-2-methanols and 1-(4,5-diaryl-1H-pyrrol-2-yl)-polyfluoroalkanones, processes for preparing them and pharmaceutical compositions | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-04-01 | — | — | EP | disclosed |