Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 11/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5374896 | 0.81 | DRD2 (0.46) | MAOAMAOBCYP2A6ABCB1 | |
| SCHEMBL266877 | 0.80 | POLL (0.50) | MAOAMAOBCYP2A6ALDH1A1MAPT | |
| SCHEMBL23023381 | 0.77 | POLL (0.50) | MAOAMAOBCYP2A6ALDH1A1MAPT | |
| SCHEMBL9958134 | 0.76 | RXRA (0.43) | ALDH1A1 | |
| SCHEMBL11735130 | 0.75 | PGR (0.43) | MAOAMAOBCYP2A6ALDH1A1MAPT | |
| SCHEMBL29320880 | 0.74 | ABCB1 (0.44) | MAOAMAOBCYP2A6ALDH1A1MAPT | |
| SCHEMBL29625728 | 0.73 | ABCB1 (0.43) | MAOAMAOBCYP2A6MAPTBRD4 | |
| SCHEMBL23515362 | 0.73 | ABCB1 (0.43) | MAOAMAOBCYP2A6MAPTBRD4 | |
| SCHEMBL7029485 | 0.72 | SRC (0.58) | — | |
| SCHEMBL18992169 | 0.72 | KDM4E (0.48) | MAOAMAOBCYP2A6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660497-A1 | [ 1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019215-A1 | [1,8]NAPHTHYRIDIN-2-ONES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-03-03 | — | — | WO | disclosed |