Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370622 | 0.80 | MAPT (0.56) | MAPTALDH1A1TDP1KMT2ACYP3A4 | |
| SCHEMBL7215729 | 0.78 | MAPT (0.53) | MAPTALDH1A1KMT2ACYP3A4BLM | |
| SCHEMBL112074 | 0.78 | KMT2A (0.70) | MAPTALDH1A1TSHRTDP1KMT2A | |
| SCHEMBL7374301 | 0.78 | MAPT (0.53) | MAPTALDH1A1TDP1KMT2ACYP3A4 | |
| SCHEMBL7374361 | 0.78 | MAPT (0.59) | MAPTALDH1A1TDP1KMT2ACYP3A4 | |
| SCHEMBL9381602 | 0.78 | KMT2A (0.63) | MAPTALDH1A1TSHRTDP1KMT2A | |
| SCHEMBL11096925 | 0.75 | MAPT (0.60) | MAPTALDH1A1TSHRTDP1KMT2A | |
| SCHEMBL7373815 | 0.75 | CDK5 (0.53) | MAPTALDH1A1TDP1KMT2ACYP3A4 | |
| SCHEMBL7369837 | 0.75 | MAPT (0.62) | MAPTALDH1A1KMT2ACYP3A4LMNA | |
| SCHEMBL7378010 | 0.75 | MITF (0.49) | MAPTALDH1A1TDP1CYP3A4BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0638123-B1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER REC TECH LTD (GB) | 2006-12-27 | — | — | EP | disclosed |
| EP-0638123-A1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1995-02-15 | — | — | EP | disclosed |
| WO-1993008288-A1 | BACTERIAL NITROREDUCTASE FOR THE REDUCTION OF CB 1954 AND ANALOGUES THEREOF TO A CYTOTOXIC FORM | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1993-04-29 | — | — | WO | disclosed |