Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 6/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 8/20 | 0.39 |
| ▸ | KIF5B | P33176 | 5/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828988 | 1.00 | KDR (0.46) | KDREPHA2EPHB4EGFRAURKB | |
| SCHEMBL5828880 | 0.94 | KDR (0.51) | KDREPHA2EPHB4EGFRAURKA | |
| SCHEMBL5828878 | 0.94 | KDR (0.51) | KDREPHA2EPHB4EGFRAURKA | |
| SCHEMBL5828053 | 0.89 | KDR (0.48) | KDREPHA2EPHB4EGFR | |
| SCHEMBL5828058 | 0.89 | KDR (0.48) | KDREPHA2EPHB4EGFR | |
| SCHEMBL7090020 | 0.84 | KDR (0.45) | KDREPHA2EPHB4EGFRAURKB | |
| SCHEMBL6981911 | 0.74 | HTT (0.48) | KDREGFRRETKIF5BRAF1 | |
| SCHEMBL7089596 | 0.73 | KDR (0.48) | KDREPHA2EPHB4EGFR | |
| SCHEMBL6985649 | 0.73 | RET (0.49) | KDREGFRRETKIF5BRAF1 | |
| SCHEMBL6980090 | 0.72 | EGFR (0.60) | KDREGFRRETKIF5BFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001904-B1 | Guanidine derivatives quinazoline and quinoline for use in the treatment of autoimmune diseases | ASTRAZENECA AB (SE) | 2006-02-21 | — | — | US | disclosed |
| EP-1296973-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AstraZeneca AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002000644-A1 | GUANIDINE DERIVATIVES OF QUINAZOLINE AND QUINOLINE FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | ASTRAZENECA AB (SE) | 2002-01-03 | — | — | WO | disclosed |