Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829663 | 0.90 | DRD4 (0.42) | OPRM1OPRD1OPRK1KCNH2PARP1 | |
| SCHEMBL5829616 | 0.87 | PARP1 (0.40) | OPRM1OPRD1OPRK1PARP1GAA | |
| SCHEMBL5829936 | 0.87 | PARP2 (0.40) | OPRM1OPRD1OPRK1KCNH2GAA | |
| SCHEMBL5829647 | 0.86 | PARP1 (0.42) | OPRM1OPRD1OPRK1PARP1TLR9 | |
| SCHEMBL5829864 | 0.86 | PARP1 (0.44) | OPRM1OPRD1OPRK1KCNH2HRH3 | |
| SCHEMBL5829605 | 0.85 | PARP1 (0.43) | OPRM1OPRD1OPRK1KCNH2PARP1 | |
| SCHEMBL5828654 | 0.81 | OPRD1 (0.51) | OPRM1OPRD1OPRK1KCNH2HRH3 | |
| SCHEMBL5630843 | 0.80 | OPRD1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5879320 | 0.79 | OPRD1 (0.65) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5629708 | 0.79 | OPRD1 (0.53) | OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008952-B2 | 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | claimed |