Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 3/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828656 | 0.90 | OPRM1 (0.41) | PARP1OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5830260 | 0.87 | PARP1 (0.46) | DRD4PARP1PARP2OPRM1OPRD1 | |
| SCHEMBL5829647 | 0.85 | PARP1 (0.42) | DRD4PARP1OPRM1OPRD1OPRK1 | |
| SCHEMBL5829616 | 0.84 | PARP1 (0.40) | PARP1PARP2OPRM1OPRD1OPRK1 | |
| SCHEMBL5829936 | 0.84 | PARP2 (0.40) | PARP2OPRM1OPRD1OPRK1CHRM3 | |
| SCHEMBL5829605 | 0.83 | PARP1 (0.43) | DRD4PARP1PARP2OPRM1OPRD1 | |
| SCHEMBL5829658 | 0.83 | OPRD1 (0.51) | OPRM1OPRD1OPRK1UBE2MDCUN1D1 | |
| SCHEMBL5879381 | 0.80 | OPRD1 (0.63) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5829864 | 0.78 | PARP1 (0.44) | PARP1PARP2OPRM1OPRD1OPRK1 | |
| SCHEMBL5631262 | 0.78 | OPRD1 (0.61) | OPRM1OPRD1OPRK1KMT2ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008952-B2 | 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | claimed |