Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828656 | 0.87 | OPRM1 (0.41) | OPRM1OPRD1OPRK1KCNH2GAA | |
| SCHEMBL5830029 | 0.86 | PARP2 (0.46) | PARP2OPRM1OPRD1OPRK1HTR2A | |
| SCHEMBL5829616 | 0.85 | PARP1 (0.40) | PARP2OPRM1OPRD1OPRK1CHRM2 | |
| SCHEMBL5829663 | 0.84 | DRD4 (0.42) | PARP2OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL5829605 | 0.84 | PARP1 (0.43) | PARP2OPRM1OPRD1OPRK1HRH2 | |
| SCHEMBL5829932 | 0.82 | OPRD1 (0.48) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5829647 | 0.82 | PARP1 (0.42) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5879372 | 0.80 | OPRD1 (0.60) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5630843 | 0.77 | OPRD1 (0.52) | OPRM1OPRD1OPRK1 | |
| SCHEMBL5629708 | 0.76 | OPRD1 (0.53) | OPRM1OPRD1OPRK1CHRM2CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7008952-B2 | 4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders | ASTRAZENECA AB (SE) | 2006-03-07 | — | — | US | claimed |