Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 2/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5828016 | 0.82 | AOC3 (0.55) | AOC3SLC6A4HTR1ASLC6A2TDP1 | |
| SCHEMBL5828705 | 0.76 | AOC3 (0.50) | AOC3CCNE2CCNE1CDK2IGF1R | |
| SCHEMBL5828700 | 0.73 | ADRA1A (0.50) | AOC3ADRA1ASLC6A4HTR1ASLC6A2 | |
| SCHEMBL521780 | 0.70 | MAPT (0.58) | ADRA1ASLC6A2ADRB3ADRB2ADRB1 | |
| SCHEMBL521779 | 0.70 | MAPT (0.58) | ADRA1ASLC6A2ADRB3ADRB2ADRB1 | |
| SCHEMBL6745741 | 0.70 | AOC3 (0.69) | AOC3SLC6A4SLC6A2MAPTALDH1A1 | |
| SCHEMBL11810215 | 0.69 | ADRB2 (0.73) | ADRA1ASLC6A4HTR1ASLC6A2ADRB3 | |
| SCHEMBL17053665 | 0.69 | MAPT (0.56) | ADRA1ASLC6A2ADRB3ADRB2ADRB1 | |
| SCHEMBL9768301 | 0.69 | MAPT (0.68) | AOC3ADRA1AADRB3ADRB2ADRB1 | |
| SCHEMBL6742350 | 0.68 | AOC3 (1.00) | AOC3SLC6A4SLC6A2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109330-B2 | Purine inhibitors of cyclin dependent kinase 2 and IκB-α | CV THERAPEUTICS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | LUM ROBERT T (US) | 2005-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050080261-A1 | Purine inhibitors of cyclin dependent kinase 2 and IkappaB-alpha | IKBKB, NFKB1, CDK4 | AOC3 3587/4885CCNE2 65/4885CCNE1 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.