Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 4/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.38 |
| ▸ | MET | P08581 | 3/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827925 | 0.92 | SIRT2 (0.48) | CDK2CCNE1PIM1HTR6CCNC | |
| SCHEMBL5828128 | 0.92 | CCNE1 (0.44) | CDK2CCNE1PIM1HTR6CDC7 | |
| SCHEMBL5828437 | 0.85 | HTR6 (0.41) | CDK2CCNE1HTR6METCCNC | |
| SCHEMBL5828511 | 0.84 | CDK2 (0.56) | CDK2CCNE1PIM1HTR6CDC7 | |
| SCHEMBL5828027 | 0.79 | PIM1 (0.47) | CDK2CCNE1PIM1CDC7DBF4 | |
| SCHEMBL5828430 | 0.75 | SIRT2 (0.57) | CDK2CCNE1PIM1HTR6CCNC | |
| SCHEMBL5828685 | 0.72 | PTGS2 (0.43) | AKT1 | |
| SCHEMBL5828116 | 0.72 | HTR6 (0.48) | HTR6CYP3A4 | |
| SCHEMBL5828106 | 0.71 | LMNA (0.41) | PIM1AKT1 | |
| SCHEMBL5828083 | 0.71 | PTGS2 (0.44) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001906-B2 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2006-02-21 | — | — | US | disclosed |
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152721-A1 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | PYM1, PNPO, IDO1 | CDK2 988/4885CCNE1 1090/4885PIM1 1680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.