Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.47 |
| ▸ | CDC7 | O00311 | 7/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.45 |
| ▸ | MET | P08581 | 3/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3050825 | 0.87 | SIRT2 (0.56) | PIM1CDC7DBF4METSIRT2 | |
| SCHEMBL5828525 | 0.85 | SIRT2 (0.59) | PIM1SIRT2CDK2PRKACAGSK3B | |
| SCHEMBL5828128 | 0.79 | CCNE1 (0.44) | PIM1CDC7DBF4METSIRT2 | |
| SCHEMBL5828893 | 0.79 | CDK2 (0.52) | PIM1CDC7DBF4METSIRT2 | |
| SCHEMBL3971688 | 0.79 | TRPM8 (0.46) | SIRT2 | |
| SCHEMBL9374063 | 0.76 | SIRT2 (0.70) | PIM1SIRT2CDK2PRKACAGSK3B | |
| SCHEMBL5828735 | 0.75 | PIM1 (0.54) | PIM1CDC7SIRT2CDK2KDR | |
| SCHEMBL5828559 | 0.74 | ALDH1A1 (0.49) | GSK3BMAPK1 | |
| SCHEMBL5827925 | 0.69 | SIRT2 (0.48) | PIM1SIRT2CDK2PRKACAGSK3B | |
| SCHEMBL5828116 | 0.69 | HTR6 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001906-B2 | Pyrido-pyrido-pyrrolo pyrrolo-indole and pyrido-pyrrolo pyrrolo carbazole derivatives, method for the production thereof and pharmaceutical compositions containing said derivatives | LES LABORATOIRES SERVIER (FR) | 2006-02-21 | — | — | US | disclosed |